GPLS 624 ONCOPHARMACOLOGY
Molecular therapy approaches will be discussed within the context of modern understanding of cancer biology and target identification. State-of-the-art approaches for cancer diagnosis and treatment will be reviewed. These include signaling pathways associated with tumor development, the role of endocrine and other receptors as drug targets, the contribution of transcriptional regulation, genome instability and DNA repair, and the harnessing of apoptotic cascades for cancer therapy. Drugs involved in cancer treatment and their mechanism of action, angiogenesis regulation, gene therapy approaches to cancer treatment, the use of stem cells and dendritic cells in therapy and immunotherapy, drug resistance, and toxicity will also be highlighted. The format is lectures followed by student discussion of assigned papers.